Jordan Turnbull and Alan McCormack were among 13 released in July, Scott Wharton and Callum Morton have returned to their parent teams, while skipper Charlie Goode became the club's first £1million pound player when he signed for Brentford.
So, with all those going one way and another nine coming in, how is the squad shaping up for Saturday's opener against AFC Wimbledon? Let's take a look...
9. Wing-back: Nicky Adams
Currently out with injury but he'll no doubt have another key role to play once he returns. Finished with 12 league assists last season and that creativity will be needed in League One.
10. Wing-back: Mark Marshall
Could be used in other positions but it appears he's minutes will predominantly come at wing-back. Could be a real ace in the pack for the Cobblers this term, particularly off the bench as his Wembley cameo proved.
11. Midfield: Christopher Missilou
The summer signing from Oldham has been Town's standout player in pre-season and he looks a shoe-in for one of the two central midfield spots. Full of energy and tenacity and will go hunting the ball off opposition players.
12. Midfield: Ryan Watson
Perhaps went under the radar last season but he enjoyed a terrific campaign, scoring seven goals from midfield including at Wembley. Will have to step it up another notch as Cobblers head into League One.