It will be far from easy with Cambridge having rallied in recent weeks to get back into the survival hunt.
But Cobblers will go into the game in confident mood after two encouraging away draws in their last two outings.
It promises to be another entertaining round of action across the league, with these results the predicted outcome according to the latest AI predictions.
Let us know your thoughts on the game and get the latest Cobblers news on our website.
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