One player that especially stands out is Ivan Toney, who came through the Northampton youth ranks in 2012 before blasting his way to the Premier League and the England squad.
Some players have done that in reverse as they drop down the leagues, with Marco Gabbiadini being one such player of note.
Here we take a look at 19 top ex-Cobblers who tasted life at the top of the game.
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13. Ian Evatt
Ian Evatt had a brief 11 game loan spell at Cobblers in 2001. Evatt was Blackpool's only ever-present player in their 38 Premier League matches during the 2010–11 season. Photo: Scott Heavey
14. Eddie McGoldrick
Eddie McGoldrick won the Fourth Division title with Cobblers n 1986/87. He would go on to bigger and better things in the Premier League with Crystal Palace and Arsenal. He played 38 games in the 1993–94 season, which included a substitute appearance in Arsenal's European Cup Winners' Cup final win over Parma. Photo: Shaun Botterill
15. Des Lyttle
Des Lyttle was part of Northampton Town 2003/04 play-off squad. He is best known for his six seasons at Nottingham Forest in the mid to late 1990's, which including time in the Premier League. Photo: Pete Norton
16. Mark Bunn
Mark Bunn made 90 Northampton Town starts between 2001-08. On 29 August 2012, Bunn joined Premier League side Norwich City and made his first Premier League appearance replacing first choice goalkeeper John Ruddy due to injury in the 82nd minute in a 1–1 draw away to Everton. Photo: Pete Norton