Two Saints starters on second Six Nations weekend
Saints lock Lawes featured from the bench in England's defeat to Scotland at Twickenham last weekend, while Biggar was at 10 as Wales beat Ireland in Cardiff.
Biggar unsurprisingly keeps his place for the game in Scotland on Saturday (kick-off 4.45pm), while Lawes steps up from the bench to start at six against Italy at Twickenham earlier that afternoon (kick-off 2.15pm).
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Hide AdEngland team to face Italy: Daly; Watson, Slade, Farrell (capt), May; Ford, Youngs; M Vunipola, Cowan-Dickie, Sinckler, Itoje, Hill, Lawes, Curry, B Vunipola.
Replacements: George, Genge, Stuart, Ewels, Earl, Willis, Robson, Malins.
Wales team to face Scotland: Halfpenny; Rees-Zammit, Tompkins, Watkin, Williams; Biggar, Davies, Wyn Jones, Owens, Francis, Beard, A Wyn Jones (c), Wainwright, Tipuric, Faletau.
Replacements: Dee, Jones, Brown, Rowlands, Botham, Hardy, Sheedy, Halaholo.