In an unusual schedule for the cup competition, Phil Dowson's side will kick-off at cinch Stadium at Franklin's Gardens on Thursday, September 8 - the day before they travel to Sale Sharks for the league curtain-raiser.
It means there is set to be a very youthful look to the black, green and gold team that takes to the field against Saracens.
Saints will also be up against London Irish, Harlequins and Newcastle Falcons in the pool stages.
Northampton Town 2 Hartlepool United 1: James Heneghan's player ratings
Opposition view: Hartlepool 'deserved more' from Sixfields clash, claims boss Hartley
Appéré strikes to seal success for Cobblers at sweltering Sixfields
Brady tinkered Cobblers' approach to cope with blistering heat in Hartlepool win
Cobblers turned down 'substantial offers' for Guthrie before defender agreed new deal
They go to Irish on a Tuesday night (September 27) and Newcastle on the weekend of November 19 with their home game against Quins scheduled for midweek (October 18/19).
Saints' Premiership Rugby Cup pool stage fixtures 2022/23
Thursday, September 8: Saracens (h), 7.45pm
Tuesday, September 27: London Irish (a), 7.45pm
October 18/19: Harlequins (h)
November 19/20: Newcastle Falcons (a)