Phil Dowson's side will face Myler's Ospreys at Brewery Field in Bridgend on Friday, September 2 (kick-off 7pm), a week before they begin their Gallagher Premiership campaign at Sale Sharks.
It is set to be a busy spell for the black, green and gold as they also face Saracens, at home in the Premiership Rugby Cup pool stage opener, on Thursday, September 8 (kick-off 7.45pm).
Saints will play two pre-season games in total, starting their preparations for the new season with a match against Bedford Blues at cinch Stadium at Franklin's Gardens on Saturday, August 27 (kick-off 2.30pm).
Northampton Town 2 Hartlepool United 1: James Heneghan's player ratings
Opposition view: Hartlepool 'deserved more' from Sixfields clash, claims boss Hartley
Appéré strikes to seal success for Cobblers at sweltering Sixfields
Brady tinkered Cobblers' approach to cope with blistering heat in Hartlepool win
Cobblers turned down 'substantial offers' for Guthrie before defender agreed new deal
Dowson's squad, minus the players who have been on international summer tours, returned to training at Northampton School for Boys on Monday morning.