Saints fly-half Biggar starts for Wales as Lawes is named on England bench
Wales will be up against Ireland in Cardiff (kick-off 3pm).
Courtney Lawes is the only other Saints player in Six Nations action this weekend.
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Hide AdThe lock is on the bench for England's game against Scotland at Twickenham on Saturday (kick-off 4.45pm).
England squad to face Scotland
15. Elliot Daly (Saracens, 47 caps)
14. Anthony Watson (Bath Rugby, 46 caps)
13. Henry Slade (Exeter Chiefs, 34 caps)
12. Ollie Lawrence (Worcester Warriors, 3 caps)
11. Jonny May (Gloucester Rugby, 61 caps)
10. Owen Farrell (C) (Saracens, 88 caps)
9. Ben Youngs (Leicester Tigers, 104 caps)
1. Ellis Genge (Leicester Tigers, 23 caps)
2. Jamie George (Saracens, 54 caps)
3. Will Stuart (Bath Rugby, 8 caps)
4. Maro Itoje (Saracens, 43 caps)
5. Jonny Hill (Exeter Chiefs, 4 caps)
6. Mark Wilson (Newcastle Falcons, 19 caps)
7. Tom Curry (Sale Sharks, 28 caps)
8. Billy Vunipola (Saracens, 56 caps)
Finishers
16. Luke Cowan-Dickie (Exeter Chiefs, 26 caps)
17. Beno Obano (Bath Rugby, uncapped)
18. Harry Williams (Exeter Chiefs, 18 caps)
19. Courtney Lawes (Saints, 85 caps)
20. Ben Earl (Bristol Bears, 8 caps)
21. Dan Robson (Wasps, 7 caps)
22. George Ford (Leicester Tigers, 72 caps)
23. Max Malins (Bristol Bears, 3 caps)
Wales squad to face Ireland
15. Leigh Halfpenny (93 Caps)
14. Louis Rees-Zammit (4 Caps)
13. George North (98 Caps)
12. Johnny Williams (2 Caps)
11. Hallam Amos (22 Caps)
10. Dan Biggar (87 Caps)
9. Tomos Williams (20 Caps)
1. Wyn Jones (30 Caps)
2. Ken Owens (77 Caps)
3. Tomas Francis (52 Caps)
4. Adam Beard (21 Caps)
5. Alun Wyn Jones (CAPT) (143 Caps)
6. Dan Lydiate (64 Caps)
7. Justin Tipuric (80 Caps)
8. Taulupe Faletau (81 Caps)
Replacements
16. Elliot Dee (33 Caps)
17. Rhodri Jones (17 Caps)
18. Leon Brown (12 Caps)
19. Will Rowlands (5 Caps)
20. Josh Navidi (24 Caps)
21. Gareth Davies (57 Caps)
22. Callum Sheedy (4 Caps)
23. Nick Tompkins (8 Caps)