Some players have done that in reverse as they drop down the leagues, with Marco Gabbiadini being one such player of note.
Here we take a look at 19 top ex-Cobblers who tasted life at the top of the game.
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1. Ivan Toney
Ivan Toney is perhaps the greatest Cobblers success story, having progressed through Town's youth ranks to the very pinnacle of the game with Brentford and England. Photo: Pete Norton
2. Marco Gabbiadini
Marco Gabbiadini played 120 times Northampton Town between 2000-03 as his career wound down. It was a career which saw him play in the Premier League with Crystal Palace before making his name at Derby County. Photo: Pete Norton
3. Kyle Walker
Walker played nine times for Northampton during a loan spell from Sheffield United. Walker is now a Premier League winner following a move, reported to be worth £45,m, to Man City in July 2017. He also has 73 England caps to his name. Photo: Pete Norton
4. Dominic Calvert-Lewin
Calvert-Lewin had a 20 game loan spell for Cobblers in the 2015/16 season. He then joined Everton in August 2016 and has racked up nearly 200 Premier League appearances. Photo: Pete Norton