The A43 in Northamptonshire has been shut northbound and traffic is now being diverted via local routes, Highways England reports.
The incident is ongoing between the A413 near Whittlebury and the A5 due to a multi-vehicle collision.
All emergency vehicles, including Northamptonshire Police, are on scene.
A spokeswoman for Northamptonshire Police said the county forcewas called at 12.17pm to reports of a two-vehicle road traffic collision involving an Audi and a Ford Fiesta.
She said: "It happened on the A43 northbound between the McDonalds roundabout and the VW roundabout.
"We don’t believe there were any life-changing or life-threatening injuries."
One lane on the Southbound carriageway is also closed.