The two clubs haven't met for five years, with their most recent clash a 1-0 for Town in Sky Bet League Two in December, 2015.
Marc Richards was the man with the only goal on that occasion, and it maintained a good run of results for the Cobblers against Stanley.
Following their return to the League in 2006, Stanley played Town for the first time in more than 48 years in August, 2009 - but they were soon to become familiar foes.
They would go on to play each other 14 times in the next six-and-a-half years, and it would be the Cobblers who would have the upper hand.
In those 14 encounters, Town won eight, drew three and lost three, with their record against Stanley at Sixfields reading P 7 W 4 D 2 L 1.
Ahead of Saturday's showdown at the PTS Academy Stadium, we have taken a look through photographer Pete Norton's archives and recall those past 14 meetings.
1. Aug 18, 2009: Stanley 0 Cobblers 3
Easy win for the Cobblers at the Crown Ground, with goals from Steve Guinan (3), Adebayo Akinfenwa (pen 18) and Billy McKay (78) Photo: Pete Norton
2. Feb 9, 2010: Cobblers 4 Stanley 0
Another big win for Town, with Billy McKay's double (57, 61) plus goals from Adebayo Akinfenwa (10) and Luke Guttridge (66) sealing it Photo: Pete Norton
3. Aug 14, 2010: Cobblers 0 Stanley 0
An early season fixture to forget at Sixfields as Ian Sampson's Town draw 0-0 Photo: Pete Norton
4. April 2, 2011: Stanley 3 Cobblers 1
Michael Jacobs (67) was on target, but by then Gary Johnson's Town were already 3-0 down Photo: Pete Norton