Alex Corbisiero will make his first start since September in Saints’ clash with Sale Sharks at the AJ Bell Stadium on Saturday.
The England loosehead prop suffered shoulder ligament damage in a win against Bath, but has returned to play a part from the bench in the past two matches.
And he has now been given the nod from the off, with Alex Waller dropping the the bench.
Saints have been forced to shuffle their pack, with an unfamiliar second row pairing of Sam Dickinson and Calum Clark lining up against the Sharks.
Regular locks Courtney Lawes (ankle) and Christian Day (back) miss out, with Samu Manoa, who can also play in the second row, on compassionate leave following the death of his brother.
Tom Wood returns to the starting 15 to take the role of captain, with Ben Nutley also in the back row, alongside Phil Dowson, who is at No.8.
Wing Jamie Elliott makes his first start since taking on Treviso in Italy on December 6 as he replaces Ken Pisi, who is named on the bench.
Sale have opted to make eight changes to the team that lost 41-16 at Wasps last weekend, with fly-half Danny Cipriani among those recalled.
New signing TJ Ioane, who moved to Sale from Otago this week, is named among the replacements.
Sale: Haley; Addison, Leota, Tuitupou, Cueto; Cipriani, Cusiter; Lewis-Roberts, Jones, Cobilas; Mills, Hines; Braid (c), Lund, Beaumont.
Replacements: Neild, de Marchi, Harrison, Ioane, Seymour, Cliff, Macleod, Arscott.
Saints: Foden; Elliott, G Pisi, Burrell, North; Myler, Dickson; Corbisiero, Haywood, Ma’afu; Dickinson, Clark; Wood (c), Nutley, Dowson.
Replacements: Williams, A Waller, Denman, Onojaife, Harrison, Hodgson, Wilson, K Pisi.