Anglian Water is warning that customers could experience interruption to their water supply today (Friday).
Mereway has been closed in both directions - and it is likely to be shut all weekend - due to a burst water main earlier today.
Anglian Water is now warning that water supply in the area could be interrupted.
A statement reads: "We're really sorry but some customers in Northampton may have very low water pressure or no water at all.
"We're working to repair a burst water main so we can get your supply back to normal as soon as possible, but it is proving to be a complex job that is taking longer than we had originally hoped."
An estimated restoration time has been given as 2pm.
A spokesperson added: "We're really sorry we've inconvenienced you and thanks for your patience."