Neighbours living near to NGH claim they are struggling to park outside their own houses some days as staff use their streets as "a free car park".
Residents of the Bouverie Estate, which is between Wellingborough Road and Billing Road, have written to chief executive Sonia Swart about the problem
Lisa Bradshaw, of Vernon Walk, said: "Carers are unable to park to carry out care visits, disabled residents cannot leave the house as they can't park when returning and emergency vehicles are also struggling to gain access for residents too."
Residents that the Chron talked to said they have written to Northamptonshire County Council to ask that the bays adopted so only residents can reserve them
But the council has said that enforcement of the roads are not a priority because of the lack of businesses in those streets.
In the meantime, homeowners who are affected are urging staff to select other parking bays off Wellingborough Road, such as those near 'The Spread Eagle' and 'Old House' pubs .
A spokeswoman for Northampton General Hospital said NGH was aware of the concerns.
She said: "It appears that the heart of the matter is whether the issues raised warrant the introduction of parking restrictions and we understand the residents are in discussion with the local authorities about that.
“In the meantime, we will be reminding our employees that we expect them to park considerately and be sensitive to the concerns of our local community.”