All emergency services are on the scene in Duston following a serious crash outside a popular pub.
The serious collision, on Bants Lane at the Poppyfield pub junction, happened at around 1.10pm today (Friday).
Police, fire ambulance crews are all on the scene and an air ambulance has landed on land off Timken South Way.
The accident involved a car and a motorbike at the junction with Duston Road just before the turn off into Duston village.
A spokesman for East Midlands Ambulance Service said: "We sent two ambulances, a fast response vehicle and an air ambulance.
"We transported one patient to Coventry and Warwickshire University Hospital, and another patient to Northampton General Hospital."
The road is currently blocked and traffic is building in the area.
A spokesman for Northamptonshrie Police said: "Motorists are advised to avoid the area and use alternative routes where possible."
Traffic is currently being diverted away from Bants Lane down Ellsemere Avenue, and traffic away from Tollgate Way onto Main Road.
Anyone who witnessed the collision or who has information about it should call 101.