Hull City striker Matty Dixon scored the only goal of the game as the Cobblers’ record-breaking FA Youth Cup run came to an end at Sixfields.
Town went out to the Tigers by a 1-0 scoreline, with Dixon doing enough to put Hull into the fifth round in a game that was postponed twice due to bad weather.
Dixon gave Hull an early lead, from which they never looked back, rolling the ball into an empty net after charging down a clearance from Dean Snedker.
The Cobblers’ first real chance of the night came on 13 minutes, David Moyo seeing a shot blocked after being played in by Jordan Chambers.
As the first half reached the midway point, Hull keeper Joe Cracknell did well to tip away a low drive from Claudio Dias.
Cracknell made a good save to deny George Craddock on 64 minutes with Ivan Toney then going agonisingly close with a volley from the resultant corner kick.
Moyo also saw a shot blocked as Craig Hinton’s side continued to ramp up the pressure on their opponents.
Harry Mattock lobbed the Hull keeper in stoppage time but his audacious chip went just over and despite their efforts the Cobblers couldn’t force the equaliser their performance warranted and it was Hull who progressed through into the fifth round.
Cobblers: Snedker, Reeve, Chambers, Dias, Mattock, Roberts, Harmon (Lamb-Johnson 78), Craddock, Moyo, Toney, Powell
Subs not used: Fitzgerald, Roland Joao, Jackson, Heath
Hull City: Cracknell, Topliss, Davie, Ricketts, Clappison, Clark, Fallowfield (Barlow 87), McCawl, Chambers, Sutton (Cardwell 75), Dixon.
Subs not used: Watson, Dawson, Penny