The Cobblers will travel to Wimbledon on Saturday with just one senior striker - Roy O’Donovan - available for selection.
The Irishman is the only centre-forward with a double-figure appearance record who is fit enough to play for Town at Kingsmeadow.
On-loan Leicester City striker Jacob Blyth is out for up to three weeks with a thigh strain and Clive Platt will be missing for around the same period of time with a calf injury.
Alex Nicholls (broken leg) is not due back until January, while club captain Kelvin Langmead, who can play up front despite being mainly used as a centre-back, is not expected back until November after undergoing knee surgery in the summer.
Ivan Toney and JJ Hooper will compete to play alongside O’Donovan, but they have only played a handful of games between them, and that could tempt Aidy Boothroyd into playing one up front.
Ian Morris has made a full recovery from his groin issue and could slide into central midfield with Danny Emerton recalled to the left wing.
There will be no immediate return to the squad for Lewis Hornby, who is yet to feature this season after sustaining a vertebrae injury over the summer.
The club will send Hornby to a back specialist for a second opinion on the problem, which is growth-related and which is currently inhibiting the central midfielder from any physical activity beyond core stability exercises.