Murray missed the opening two matches against Wales and France with a rib injury but came through 80 minutes of his club's Guinness Premiership defeat at Wasps on Sunday unscathed.
There is also a recall for Glasgow captain Alastair Kellock, who w
ill make his first Test start for two years due to a shoulder injury to Edinburgh lock Jim Hamilton.
Murray and Kellock are the only two changes from the side beaten 22-13 in France just over a week.
Saints back-rower Scott Gray is again on the bench while there is no place again for Franklin's Gardens team-mate Sean Lamont.
Scotland: H Southwell (Edinburgh); S Danielli (Ulster), M Evans (Glasgow), G Morrison (Glasgow), T Evans (Glasgow); P Godman (Edinburgh), M Blair (Edinburgh, capt); A Jacobsen (Edinburgh), R Ford (Edinburgh), E Murray (Northampton), J White (Sale), A Kellock (Glasgow), A Strockosch (Gloucester), J Barclay (Glasgow), S Taylor (Stade Francais). Replacements: D Hall (Glasgow), A Dickinson (Gloucester), K Brown (Glasgow), S Gray (Northampton), C Cusiter (Perpignan), C Paterson (Edinburgh), N De Luca (Edinburgh).
