The A43 near Towcester has reopened in the northbound direction after a crash involving three vehicles.
The crash, which involved a Mazda, a Mercedes and a van, happened near to the McDonalds roundabout at 1.45pm.
All three emergency services were called to the scene and the fire service released two people from their vehicles.
A police spokesman said none of the injuries were believed to be life-threatening.
Drivers were advised to use alternative routes as there was a long queue of traffic from the A5 to the Silverstone junction.