Motorists are being urged to avoid the A5 between Weedon and Towcester after a crash closed the road.
The emergency services were called to the road at shortly after 1.30pm after a car and lorry collided near the Furnace Lane junction to Nether Heyford. The lorry ended up in a hedge.
Police at the scene say no one was injured.
The A5 is currently closed between Heyford Lane near Weedon and the A43 at Towcester and motorists are being urged to take alternative routes.