The former Northampton School for Boys pupil will be joined by Karen Gillan, who plays his new assistant Amy Pond in the hit show, when the Doctor Who tour bus pulls into town on Wednesday, March 31.
The BBC has not yet announced where in Northamp
ton the special screening will be held or how people can get hold of tickets, but those lucky enough to get in will be able to see the first episode of the show's latest series three days before its expected TV debut.
The show's executive producer, Piers Wenger, said: "This is a great opportunity for the new Doctor and his companion to meet the people who matter most to Doctor Who, the fans.
"And the chance for Matt to meet the fans in his home town will ensure the Doctor's maiden voyage is an utterly magical one."
As well as watching The Eleventh Hour, the first episode of the 31st series of Doctor Who and the first to feature Matt in the title role, people who get into the premiere should also get the chance to meet the show's two new stars.
Although none of the episodes for the new series have yet been completely finished, it has been revealed the first episode will be 20 minutes longer than a usual episode of Doctor Who and will see Matt Smith's Doctor meet his new assistant for the first time.
Internet rumours have also suggested the episode may feature a shape-shifting dog and be set across three time zones.
In the latest episode of Doctor Who Magazine, Mr Wenger admitted even the new stars of the show had been nervous about watching early versions of the programme.
He said: "One of my favourite moments in recent months was when we all sat down together to watch a really rough version of the Eleventh Hour.
"Matt and Karen sat on the sofa, hiding behind their hands, and we all ate pizza, drank wine and had a brilliant time. I couldn't think of a nicer bunch of people to be spending my time with."
Later this month, the Chron will reveal exactly where the exclusive Northampton screening will be held.